2cb cross tolerance I did around 2g of shrooms (lemon tek) last thursday, and am planning to do 2cb this saturday. Just make sure to up the 2C-B dose a bit to combat tolerance. 2cb barely creates any tolerance for itself or other psychedelics. 2cb primarily acts on one receptor site -- 5-HT2c, whereas LSD and mushrooms act on 5-HT2a, 5-HT2b, and 5-HT2c so tolerance developed from doing LSD and mushrooms first negates 2CB effects more than 4-Bromo-2,5-dimethoxyphenethylamine (also known as Nexus, Bromo Mescaline, BDMPEA, Venus, and 2C-B) is a novel psychedelic substance of the phenethylamine class. Posted by u/xtcthclsd - 2 votes and 3 comments The 2C group (of which 2C-B is the only one regularly seen used recreationally in the UK) are synthetic psychedelic phenethylamines that are sometimes sold as ‘party pills’ that have similar effects to Ecstasy or LSD. Mazzab Please note that this is NOT for 2C-B-FLY or βk-2C-B discussions, they may have 2C-B in the name but these are completely separate substances. They can be used a couple of times in a short space of time without massive tolerance 2C-B will produce cross-tolerance on par with most other psychedelics. If you're taking the dpt orally then do it after the 2cb. A few days earlier I did 2C-B, could that be the reason? Posted by u/iamokamor - No votes and 15 comments LSD before 2C-B = cross tolerance. Here, we aimed to assess tolerance and cross-tolerance to HTR elicited by psychedelic and nonpsychedelic serotonin 2A receptor (5-HT 2A R) agonists Cross-tolerance to phenethylamines has only been proven in mescaline , but there are numerous user reports of cross-tolerance within this group. In the future wait a week since your last lsd dose. All psychedelics are cross-tolerant, and so using Mescaline and then 2C-B would be almost the same as using 2C-B two days in a row, or Mescaline two days in a row. Plus im trying to keep my drug usage minimal . 2c-b itself does not build a tolerance to itself, so you could take it two days in a row without problems. There would be a cross-tolerance present between 2C-B and other psychedelics, but once a week on just 2C-B is fine :). Tried 2cb for the first time last night (13mg) and was pretty underwhelming, no visuals and mainly just felt very light. i assume that all psychedelics have somewhat of a cross tolerance as they all act on the same 5HTA2 receptor (as well as Hello everyone I plan on taking some shrooms and a few days after that nexus flipping. Reply . It would be too intense for a lot of people IMHO. As 2CB indeed nearly doesn’t build tolerance at all Reply reply LSD has cross tolerance with other psychedelics and tolerance to itself, this is reported by the vast majority of users. I dont really know why, but its similar to the weird cross-tolerance you get from LSD/2C-B. 2C-B (and apparently 2C-C) works a bit differently than your average psychedelic and won't build psych tolerance when taken but will be effected by any tolerance you already have. Reply reply Unless you've absolutely wrecked your serotonin system through MDMA overuse, there's no cross tolerance. ecstacylover Bluelighter. to try the 2cb alone beforehand because im planning on doing all this next weekend and dont want to have any tollerance/cross-tolerance issues. 2C-B is one of a few psychedelics to break that pattern, along with DMT and a select few others. Psilocybin causes cross-tolerance with LSD and mescaline, the psychoactive I took a micro dose (50mg) of mescaline Monday, and I might be doing a small dose (15mg) of 2cb with some friends in a few hours. Recently, I tried 2C-B for the first time. I was under the assumption I'd have to take ~3x the amount of 2cb to trip properly but that wasn't the case. you would be able to take LSD again at this point and be all good Additional comment actions. 2cb builds tolerance very slowly. 2C-B & Physical Addiction: Dependence & Tolerance. So would waiting a week be fine to have the same effects from the same dose? (Same for LSD) Keep in mind there is a cross tolerance between most psychedelics. We are here to discuss all things related to the chemical 2C-B-FLY, a psychedelic phenetylamine of the 2C family. Much science was spilled backing this up. If I dropped LSD three days before, is there any cross tolerance? I read that if you drop 2cb first, there shouldn't be any cross 62K subscribers in the 2cb community. Some more so than others. However, acid before 2cb is a no go. While 2C-B also operates on your serotonin system, it does so in a different and less demanding way - by plugging itself into your serotonin receptors rather than forcing a mass release of actual serotonin as MDMA does. It is perhaps the most well-known member of the 2C-x Please note that this is NOT for 2C-B-FLY or βk-2C-B discussions, they may have 2C-B in the name but these are completely separate substances. 2c-b doesn’t interfere with your LSD if you do 2cb first, and then later in the week dose your acid, but not vice versa. All psychedelics, except DMT, have a cross-tolerance. My strong suggestion is to do one day sober. We require accounts to be at least a week old to prevent spamming & sourcing from new accounts, so a moderator will manually review this post before it Last Friday I took ~400ug lsd and plan on taking a few 2cb pills this Friday. In fact in my experience 2cb actually enhances sexual performance. 2cb is such an expense that you want to be maximizing what you get out of it. e. " if i wanted to take lsd first and 2cb at hour 3 of lsd trip. Members Online. /r/2CB_FLY or /r/researchchemicals are the subs for Usually if you did lsd the night before 2cb, it wont work as well and will be a waste but in this case because you took such a small amount I think you wont see much of a cross tolerance. What is weird is how crazy drastic the cross tolerance is. 2c-b Week 4. They mix well. 2c-b does not generate much cross tolerance or tolerance to itself, based on the experience of the vast majority of its users. Menu. The original and only subreddit dedicated to 2C-B, the psychedelic phenethylamine synthesized by Alexander I did acid saturday and I got some 2cb ,I was wondering when can I take 2cb without any cross tolerance. After 2cb anything goes, including 2cb. Week 3. yes, there is cross tolerance between (various) types of psychedelics and even MDMA/XTC/2CB (and the likes) belongs to that list (although somewhat weaker) in general, one can say that after taking psychedelics/mdma you have to wait (at least) 3 full days to “2C-B does not produce cross-tolerance with other serotonergic psychedelics, although most users report other psychedelics affecting 2C-B tolerance. The Southern California Sunrise Recovery Posted by u/Appropriate-Plane-69 - 1 vote and 8 comments Cross-Tolerance across Drug Classes. So taking 2C-B is more likely to reduce the effects of LSD than taking more 2C-B. Of all psychedelics, 2C-B is It has a one sided x tolerance - lsd and shrooms build tolerance for 2cb but 2cb does not build tolerance for lsd/shrooms. After LSD, wait the usual two weeks to return to baseline. I did 440ug LSD 2 days ago and want to do some 2CB today, how much will this affect my 2cb trip? since we're talking about cross tolerance between phenetylamines and lysergimides. Is there a cross tolerance from traditional psychedelics and 2CB Cross tolerance after 2C-B? MDMA + 2C-B Yesterday I took MDMA for the first time in over a year, so I expected to be swept off my feet. MDMA and 2CB is a good combo as reported. But nothing really happened. 58K subscribers in the 2cb community. It would be less potent than usual but combining it with mdma would bump it back up a bit. 2C-B is notable for barely building any tolerance to itself, let alone other 2c-b’s cross tolerance with LSD also works a little weird. 2CB before LSD = trip indeed LSD before 2CB = sad me. Users suggest that one’s tolerance to 2C-B resets after 48 hours. i've had it at this dosage before and just found it to be a very light experience all together (possible LSD tolerance at the time). 56K subscribers in the 2cb community. I've heard Posted by u/[Deleted Account] - 4 votes and 2 comments On the whole I have found the cross tolerance between 2CB and empathogens to be more of a synergy really. I heard there was cross tolerance from mescaline to lsd and i thought it could also carry onto 2cb, but it does make more sense tht wot i heard was wrong and tryptamines and phens dont have cross tolerance. (2013, Jan Posted by u/jdoebe - 1 vote and 1 comment Thank you for including so much detail! That’s interesting because that’s kind of similar to the issue with taking acid and psilocybin with SSRIs (just in the sense that you wouldn’t feel it because you would have a tolerance already) I think in this case I’ll revisit trying 2cb when I’ve finished my course of antidepressants just because I’d love to have a good first experience I had a number of experiences with psychedelics (2CB and LSD) both at parties setting and in quiet, meditative introspective settings. Drug Combination 2C-B mimics serotonin at 5ht-2a serotonin receptor site and so it makes sense that another agonist at this site like LSD would provide a cross tolerance. I know psychedelics share cross tolerance. 00 followed Like other psychedelics, βk-2C-B is regarded as non-addictive and subsequent dosing intervals will generally increase tolerance to βk-2C-B and other psychedelic substances. Multi-day parties are not like one day raves, it's not a non-stop rager. It has cross tolerance with psychedelics such as LSD and psilocybin mushrooms but this tolerance is more noticable if you use either of those two before you use 2cb. Shrooms/2cb cross-tolerance . I’d read a lot about this cross-tolerance stuff, and the general consensus seems to be that “Phenethylamines build tolerance slowly and only affect tryptamine tolerance a little bit. We require accounts to be at least a week old to prevent spamming & sourcing from new accounts, so a moderator will manually review this post before it is made public. 2cb tolerance is more flexible, you can redrop in the same night and/or trip more days, you just have to increase doses. And how much should I wait to drop acid I tried 2cb for the first time yesterday, took 20 mg as did two of my friends and the effects were pretty negligible. The original and only subreddit dedicated to 2C-B, the psychedelic phenethylamine synthesized by Alexander Basically the title, do any of them affect the other if taken, for example at a festival in order: 2cb/LSD 2cb/LSD MDMA I understand all the warnings Hi, probably been answered countless times before but can't find anything related. It was first synthesized in 1996 by Aaron P. Ive never tried 2cb and it will be at a rave. Both have empathogenic qualities and synergize incredibly well. Ime acid after 2cb is still feasible. Posted by u/jonnyorkshire - 1 vote and 2 comments So i heard there was a cross tolerance between lsd and 2cb, but i don't really understand how it works. I do microdose shrooms every day and dosed 2g of some potent APE 2 days prior so wondering if that could cause a cross tolerance or if I went into the experience with over-expectations. Posted by u/Brando2295 - No votes and no comments Zero cross tolerance with Mdma. We were planning a big weekend. In terms of mdma; it won't build tolerance to it because it works in a different way Furthermore, pretreatment with either 8-OH-DPAT or DOI produced cross-tolerance to LSD. The original and only subreddit dedicated to 2C-B, the psychedelic phenethylamine synthesized by Alexander To the tolerance, yes there is cross tolerance but it's better if you take the 2c-b first because tryptamines (LSD) build up stronger tolerance than phenetyamines (2c-b) That means if you would take LSD before 2cb you will feel like 50% of the 2cb And if you take 2cb before LSD you will feel about 75% of the lsd the problem is the cross tolerance. They can be used a couple of times in a short space of time without massive tolerance build. lypqge vnde cyuaci ibx nzcyt fqtw zfxdiwfs mah omqpl oniw raaigq glbz kvunpizl pxedcd dvtzt